Serine 338 Phosphorylation Is Dispensable for Activation of c-Raf1
نویسندگان
چکیده
منابع مشابه
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
We have previously shown that inhibition of phosphatidylinositol (PI) 3-kinase severely attenuates the activation of extracellular signal-regulated kinase (Erk) following engagement of integrin/fibronectin receptors and that Raf is the critical target of PI 3-kinase regulation [1]. To investigate how PI 3-kinase regulates Raf, we examined sites on Raf1 required for regulation by PI 3-kinase and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m209951200